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The cash deal comes on the heels of Bristol-Myers Squibb Co’s agreement last week to buy Celgene Corp for $74 billion in the largest pharmaceutical deal ever, spurring investors’ hopes of a new wave of large healthcare acquisitions. Loxo gained prominence in 2017 – just three years after going public – with impressive clinical trial results showing its drug to be highly effective on cancers driven by a single gene mutation known as TRK fusion, regardless of where in the body the tumors originated best luxury cufflinks.
These patients, with more than 17 different types of advanced cancer but all with the same genetic mutation, had run out of other treatment options. Yet some 80 percent who received Loxo’s first drug, a pill called larotrectinib, experienced dramatic, often long-term improvement best luxury cufflinks. The Connecticut-based company won U.S. approval in November for the treatment under the brand name Vitrakvi, which is sold in partnership with Bayer AG. Lilly said it “very much” wants to continue the agreement with Bayer, which sells Vitrakvi outside the United States and shares U.S. commercial costs and profits with Loxo..
Loxo is also developing LOXO-292 targeting a different rare gene mutation, and analysts have forecast eventual annual sales of over $1 billion. Lilly would gain full control of that drug as it is not part of Loxo’s Bayer collaboration. In an interview, Lilly Chief Executive David Ricks said that drug targeting a mutation known as RET, seen in thyroid, lung and other cancers, was a major driver of the deal. It received breakthrough therapy designation from U.S best luxury cufflinks. regulators, which could speed its path to approval..
Loxo was quick to take advantage of new technologies that can isolate genetic drivers of tumor growth, and the willingness of regulators to approve treatments across tumor types when a specific defect is present, Ricks said at the annual JPMorgan Healthcare Conference in San Francisco on Monday. “Loxo sort of predicted that and then capitalized on that in a way that created value,” Ricks said, adding that the acquisition will help Lilly identify new targetable mutations. He said Lilly was also interested in expanding in immuno-oncology through its own research and possible deals best luxury cufflinks.
Targeted therapies offer the promise of potentially dramatic results if patients most likely to benefit are correctly identified, and are seen as a potential alternative to chemotherapy and its many adverse side effects. “The acquisition of Loxo, along with last week’s acquisition of Celgene, may represent the cream of the crop in biotech being harvested by big pharma,” IFS Securities analyst David Bouchey said. “The size of the deal may indicate Lilly’s willingness to pay up to out-bid the competition.” best luxury cufflinks.